Cryopreserved Human Hepatocytes

Cytes Biotechnologies, S.L. offers cryopreserved hepatocytes well characterized and qualified for key applications in different formats:

  • Cryopreserved Suspension Hepatocytes (Male/Female)
  • Cryopreserved Plaeble Hepatocytes (Male/Female)
  • Cryopreserved Plaeble Hepatocytes - Induction certified (Male/Female)
  • Cryopreserved Plaeble Hepatocytes - Induction & Transporter certified (Male/Female)

Product characteristics:

• Rigorous QC standards.
• Extensive application based characterization
• Proprietary media for recovery, plating and maintenance
• Tested for yield, viability, and morphology

Human cryopreserved hepatocytes are stored in liquid nitrogen vapor (-150°C or colder).

Cryopreserved human hepatocytes are used in the following studies:

  • Acute Cytotoxicity Assessment.
  • Prediction of Hepatic Clearance.
  • Prediction of Fraction Metabolized (fm) close to in vivo.
  • Hepatocytes in suspension allow evaluation of donor-specific uptake transporter inhibition and CYP inhibition.
  • Evaluation of Repeat Drug Exposure.
  • Plateable cryopreserved hepatocytes allow the evaluation of chronic exposition to drugs by the measurement of inflammatory signals.
  • Study Donor dependent Drug Metabolism and Induction.
  • Plateable cryopreserved hepatocytes allow the evaluation of inter-individual variations in drug metabolism enzymes (DMEs) and response to inducers.