HUMAN NON PARENCHYMAL CELLS

Kupffer Cells 

Kupffer cells are the specialized macrophages residents in the liver, lining the walls of the sinusoids. 

These cells are part of the mononuclear phagocytes system and can be activated to produce inflammatory cytokines, growth factors and reactive oxygen species.

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Hepatic Stellate Cells 

Stellate cells are the major cell type involved in liver fibrosis in response to liver injury and they play a key role in the homeostasis of liver extracellular matrix, repair, regeneration and fibrosis, and control retinol metabolism, storage and release.

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Liver Endothelial Cells

The liver contains two distinct endothelial cell types: vascular (LEC) and sinusoidal (LSEC). 
Liver Endothelial cells (LEC) are highly specialized endothelial cells representing the interface between blood cells and the rest of liver cells. Liver Sinusoidal Endothelial cells (LSEC) are microvascular endothelial cells which, in physiological conditions, regulate hepatic vascular tone contributing to the maintenance of a low portal pressure during digestion.
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Mix NPC's

Hepatic non-parenchymal cells (NPCs) represent about 30% of the liver and are specialized cells which interact with hepatocytes for several functions. For this reason, liver co-cultures may increase the sensitivity of liver models for ADME/Tox-related research by recapitulating the complexity of a whole liver. 


"Mix NPCs" provides a mix of different types of liver cells, including Kupffer cells, liver endothelial cells and Stellate cells.
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MSDS
CoA
Protocols
MSDS
CoA
Protocols

Non Parenchymal Cells

Non-parenchymal cells (NPCs) isolation enables the possibility to obtain liver models mimicking the microenvironment and microanatomy of the human liver for the study of liver functions. Moreover, these models present organotypic hepatocyte-NPC interactions via direct contact or paracrine signalling. Therefore, these models are able to recreate the physiological in vivo environment and this is a fundamental requirement to obtain a specific predictive response for the study of liver physiology/pathology or to perform new drug screenings and safety analysis with a high predictive value.


Cell types:

-Kupffer cells
-Stellate cells
-Liver Endothelial cells
MSDS
CoA
Protocols
MSDS
CoA
Protocols

Hepatocytes Media

Non-parenchymal cells (NPCs) isolation enables the possibility to obtain liver models mimicking the microenvironment and microanatomy of the human liver for the study of liver functions. Moreover, these models present organotypic hepatocyte-NPC interactions via direct contact or paracrine signalling. Therefore, these models are able to recreate the physiological in vivo environment and this is a fundamental requirement to obtain a specific predictive response for the study of liver physiology/pathology or to perform new drug screenings and safety analysis with a high predictive value.

Cell types:

-Kupffer cells
-Stellate cells

-Endothelial cells

Kupffer Cells 

Kupffer cells are the specialized macrophages residents in the liver, lining the walls of the sinusoids. 

These cells are part of the mononuclear phagocytes system and can be activated to produce inflammatory cytokines, growth factors and reactive oxygen species.

Contact

Hepatic Stellate Cells 

Ready-to-use media designed for plating cryopreserved human hepatocytes providing an optimal attachement and monolayer formation. 


Contact

Endothelial Cells

The liver contains two distinct endothelial cell types: vascular (LEC) and sinusoidal (LSEC). 
Liver Endothelial cells (LEC) are highly specialized endothelial cells representing the interface between blood cells and the rest of liver cells. Liver Sinusoidal Endothelial cells (LSEC) are microvascular endothelial cells which, in physiological conditions, regulate hepatic vascular tone contributing to the maintenance of a low portal pressure during digestion.


Contact

 Mix NPC's

Hepatic non-parenchymal cells (NPCs) represent about 30% of the liver and are specialized cells which interact with hepatocytes for several functions. For this reason, liver co-cultures may increase the sensitivity of liver models for ADME/Tox-related research by recapitulating the complexity of a whole liver. 

"Mix NPCs" provides a mix of different types of liver cells, including Kupffer cells, liver endothelial cells and Stellate cells.


Contact