We are happy to announce that we have 3D Spheroid qualified Hepatocytes available at 2D price until August 31th! 3D cell models are characterized because their goal is to mitigate the gap between specific cultures and complex native in vivo environments, such as the liver. 

In general, it has been determined that 3D culture improves hepatocyte functions, probably due to the establishment of intercellular homotypic contacts and the presence of key components of extracellular matrix in and around the system. In this respect, it is noteworthy that these 3D models include spheroids. Spheroid culture system represents a progressive research tool and consists in inhibiting the binding of hepatocytes to the flat surfaces of the culture plates, forcing their flotation as aggregates. This culture system improves and promotes the retention of most parenchymal functions, together with the biotransformation activity of phase I and II, for at least three weeks later of planting. 

For this reason, spheroids are part of the cutting-edge of 3D hepatic cell culture which provide the best cellular functional lever for physiology and pathological studies, as well as drug discovery and toxicology with high predictive value.